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Themed collection Coronavirus articles - free to access collection

156 items - Showing page 1 of 3
Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

不过,这一涨幅显著低于此前一个月8.2%的环比涨幅。
It’s wall-to-wall pure pop heaven, crackling with originality and dark humor, teeming with action sequences so perfectly timed and executed you almost want to run out of the theater on the spot so you can call a friend and rave about it — but you wouldn’t dare leave your seat because you wouldn’t want to miss a frame of this brilliant, pulse-quickening gem.

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

The potential for conflict will force China and the US to redefine their roles in a shifting environment that neither is comfortable with. Tensions will be aggravated by anti-China sentiment during the American elections. Asian countries are in a position to delineate the boundaries of influence for these two powers but, given their varied interests, alliances will shift depending on individual concerns.
Everyone was hugely cheered that global greenhouse gas emissions were flat between 2014 and 2016, even though recorded global growth was OK. The trouble is that this wasn’t the improvement in global economic efficiency everyone celebrated, but just a slowdown in northern China. As this part of the world recovered its economic mojo in 2017, carbon dioxide levels began to rise again.

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
From the themed collection: 购房签补充协议 应提前看清
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

10. Taitung, Taiwan-The footbridge which connects small, uninhabited Sanxiantai Island to Taitung is celebrated for its eight looping arches. This coastal county is in Lonely Planet's list of top destinations in Asia to visit in 2016.

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

Targeted poverty alleviation

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

adj. 永久的,永恒的
The auction house said today that the auction, featuring two diamonds over 100 carats, drew buyers from more than 30 countries.
7. Love is like two people holding two ends of a rubber band: it’s always the one who doesn’t let go who gets hurt more.
这项预计于2016年1月1日生效的修正案,包含一个子条款:为生二孩的夫妻延长生育假和其它福利。这些政策有望提高一些夫妻生二孩的意愿。然而,由于抚养两个孩子的成本会更高,并且女性生二胎还要担心公司老板会有看法,所以许多夫妇都表示不愿意再生。

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

英国
But there's little doubt this was also an 'acqui-hire,' in which the person being bought is just as important as the product. D'Aloisio is now working full time in Yahoo!'s London office, and his youth, his energy and his undeniable it-factor have brought the formerly musty tech giant a much-needed injection of cool. Yahoo! CEO Marissa Mayer -who lends the company some of her own it-factor-praises his 'commitment to excellence in design and simplicity' and says she is 'inspired by the creativity and tenacity Nick brings to his work.'
The research also suggests there maybe a value in finding a job through an internship. Interns who accepted a job offer had higher salaries than those who had received an offer but refused it. Those interns who did not receive an offer had lower salaries still. The gap between these groups had increased three years after graduation.
British business schools make up ground on their French counterparts in the revamped Financial Times ranking of masters in management degrees.

Graphical abstract: Trends and targets in antiviral phototherapy
From the themed collection: 家居消费频现“私单”骗局
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

Some Brexiters and Republicans believe in the ideal of absolutely free markets.

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

如果我们问你“你想要多少月薪?”你应该说随便,或是根据工作责任而定。除非我们逼你,别自己说出一个具体的数。因为那只会让我们在商量上面占上风。

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

ex出,ceed走-走出去到美国学习-超过一般人
The overall 2018 ranking encompasses more schools than ever before – 1,250 universities located across 74 countries. This is an increase from the 1,000 schools in 65 countries included in last year's edition.

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

Some of them still give high return to their shareholders. China Merchants Bank is generous; its dividend reached 30.16% of its net profits.
[ai'dentik?l]

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

喜剧类最佳剧集:《副总统》(Veep, HBO)
穆里埃塔属于一个叫“五皇后”的黑帮,他们是加州淘金热的高潮期间,臭名昭著的土匪。虽然穆里埃塔的犯罪行为可能没有任何政治色彩,他还是随着来到加州投机的美国定居者,成了墨西哥抵抗的象征。对他而言,这可不是什么好事,而是促使政府悬赏他的人头,导致他被杀和斩首。幸运的是,班德拉斯的角色没有遭到同样的命运。

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

['benifit]
大多数成功的创业者都遵循类似的模式,并且具备类似的基本特质。无数在线文章和图书宣称掌握了商业成功的秘诀,但事实上其中大多数都可以归结为几个相同的要点。
The 2017 grads of Tsinghua University earn an average salary of 9,065 yuan per month, according to the survey released by xinchou.cn, an internet salary survey and report provider.
*最佳真人秀主持:鲁保罗?查尔斯(RuPaul Charles),《鲁保罗变装皇后秀》(RuPaul’s Drag Race, Logo)

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

新闻网站PharmaLetter 援引艾美仕医疗信息研究所的话报道,“医药新兴市场”在医药方面的支出费用将在未来5年上升百分之五十以上。

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

“The Diary of a Teenage Girl” (Marielle Heller)
《泰晤士高等教育》专刊的编辑菲尔·巴蒂说道:“中国采取了强有力的政策,且背后又有雄厚的资金支持,才能打造这些世界一流的大学。2015年,中国就宣布将实施‘卓越计划',计划在2020年之前打造六所可以跻身世界一流行列的高校。”

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

The 2018 Academic Ranking of World Universities released last Wednesday by Shanghai Ranking Consultancy reveals that 62 research universities in China have made their list of the world's top 500 universities.

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

各大资产管理公司的专家们表示,评估亚洲ETF潜力的难题在于日本市场在地区所占比重过大,以及日本央行(Bank of Japan)扮演的角色过大。日本央行每年购买6万亿日元(合540亿美元)的ETF,这扭曲了市场。

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

2010年,马丁飞行器公司推出的喷气背包号称"世界上第一个盗版喷气背包"。这个喷气背包甚至还被列入《时代周刊》"2010年度50强发明"之一,因为众所周知世界上第一个喷气背包是在1958年发明的,且自1981年来一直在发展。喷气背包由温德尔·穆尔设计,他是贝尔空间系统公司的研究员。温德尔设计的喷气背包的早期模型飞行高度可达5米(16英尺),飞行时间为3分钟。这一点引起了美国军队的注意,美国军队便为这一项目投资了15万美元。后来,还特地为美国军队做了些试飞飞行器,也为肯尼迪总统做了飞行器。之后,因为飞行时间和飞行距离有限,美国军队取消了对这个项目后续研究的投资。美国航天局也想用喷气背包为阿波罗11号任务做支援,以防登机舱出故障。但之后还是改变了想法,改用了月球车。贝尔经历了这个挫折后,停止了对飞行器的进一步研究。
理由有两方面:首先,从逻辑上讲,你实在有太多的机会被人抓住你在搜索工作。简历的副本会被发现。计算机服务器会被检查。工作伙伴会从表面上或者情绪上(多半是后者)察觉到你为面试而心不在焉。
“The worker threw a brick through the window with the words ‘I quit’ written on it.”
A happy New Year to you.

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

波多黎各人自前任总督的过去4年受到了几十项新税收的影响,还增加了水电费。加西亚·帕迪利亚设法为政府创造更多的收入,他说资金正在用尽。尽管有某些和那些措施,岛上政府已经违约上百万美元的债券付款,数个机构宣布进入紧急状态。
在那之前,她曾出演过大受欢迎的情景剧,并且也因饰演的角色而小有名气。
n. 非法移民
That even at a lower profit margin (say, 40%) and a 1/3 cannibalization rate (i.e. customers buy one third fewer full-priced iPhones), the cheaper iPhone would increase Apple'srevenue and gross profits (see her spreadsheet above).
n. 基金;资金,现金(fund的复数) v. 提供资金

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

5.电子烟
I can well imagine that in 2016 the oil price will bounce back from its current sub $40 level. The Saudis may try to cut production, there could be more conflict in Iraq, terrorists could attack some of the prize targets such as the oil terminals at Ras Tanura and Abqaiq. Anything is possible, something is likely. But the question is how far the bounce will go.

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

Justin Bieber's split from Selena Gomez was the most enquired-about relationship bust-up while Victoria Pendleton beat Georgia Salpa as the most searched-for participant in a reality television show.

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

He failed to do so and Presti smartly moved on while he could still recoup some value.

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

节目1 开场曲《欢歌贺新春》,中央电视台48位主持人
该杂志称,他的净资产为35亿美元,与前一年相比缩水了10亿美元。
美国太空探索技术公司取得了一项令人难以置信的成就。“猎鹰9号”发射器的一级火箭在成功将货物运送到国际空间站后,能够自主转向,释放了主发动机燃烧提供的巨大动能,飞回地球并垂直降落在漂浮在大西洋上的一艘相当小的自动驳船上,极其精准。
Audrey Zhang, a fifth-grader from Levittown, N.Y., is the winner of this year's Doodle 4 Google competition, rising to the top of some 100,000 entries on the theme of "draw one thing to make the world a better place."

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

How you think about your workbeing very popular in the west?
Unemployment was the most searched for financial item, followed by "Wall Street companies" and "recalls".
托米?韦素与格雷戈?泽斯特洛在旧金山一堂表演课上相识。格雷戈梦想着能在好莱坞崭露头角,搬来了旧金山,加入了托米的电影拍摄。托米自己出资,自导自演了《房间》(The Room)这部电影,后来该电影被批得体无完肤,很多人视其为邪典电影的经典。
In the season of joy I present my sincere wishes and kind thoughts. May the kind of New Year outshine all the rest.

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

这是第二枚被拍卖的诺贝尔和平奖奖牌,得主是第一个获得该奖项的拉美人——1936年诺贝尔和平奖奖牌被授予当年的阿根廷外长卡洛斯·萨维德·拉莫斯。
大银行已经或多或少地放弃了用高薪留住人才的尝试。自金融危机以来,有一件事很清楚:如果你想暴富,就得去硅谷。露丝波拉特(Ruth Porat)在2015年树立了一个标杆,她放弃了摩根士丹利(Morgan Stanley)首席财务官约1300万美元的年薪,跳槽谷歌(如今的Alphabet)获得五倍于此的薪酬。

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

[.reidi'ein]
Justin Bieber's split from Selena Gomez was the most enquired-about relationship bust-up while Victoria Pendleton beat Georgia Salpa as the most searched-for participant in a reality television show.
Kate Winslet is another Brit who’s opted for the loo for her best actress Academy Award, which she was awarded for her complex role as a concentration camp guard in the 2008 adaptation of Bernhard Schlink’s novel, The Reader.
骑行背带可以取代折叠式婴儿车和大背带,带孩子外出时携带这些物件常让家长感觉更加笨重麻烦。
New employees at the company's Tulsa headquarters have little time to be shy: on their first days, they're seated at desks with a tub of candy. Colleagues often stop by and introduce themselves while grabbing a snack.

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

But national and racial identity were often conflated for the white majority. That identity felt to many white people like one of the most important pillars holding up their world — and now it seems under threat.
荷兰合作银行表示,在本月唐纳德.特朗普(Donald Trump)当选美国总统后,该行对美国的前景持谨慎态度。
It is the first time in the rankings’ 19-year history that two schools have between them held the top two spots in both categories.

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

securities
那么,当你看到17岁的尼克?达洛伊西奥(Nick D’Aloisio)意气风发地走进伦敦巴尔?布鲁(Bar Boulud)餐厅,与人坚定地握着手,描绘他未来事业蓝图的时候,你应该会惊讶得合不拢嘴了吧。他就像是个来自硅谷的首席执行长(CEO),应对媒体时从容不迫,技巧上可以打97的高分。聊天时,他眼神坚定地注视着你,从诺姆?乔姆斯基(Noam Chomsky)的理论、神经网络科学,到移民心态乃至佛教瑜伽,他一切话题都能自信地畅所欲言。但他又像是个One Direction男孩组合的成员,修长的身材配着嬉皮T恤和修身小西装,头发凌乱地搭在脑门前,一边咬着吉士汉堡,一边发表着让人瞠目结舌的见解。

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

['t?ksik]
Technology and telecoms are on the up as are some fast food companies, including Starbucks, which BrandZ puts in this category, and McDonald's, whose brand value is risen by nine per cent even though its ranking is unchanged.
排在第八位的是29岁的中国模特刘雯,她的收入为650万美元,她是榜单上唯一一位亚洲模特,这也反映了缺少多样性的问题依然影响着模特界。

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

●“Girl Infects 586 Men With HIV On Purpose, Plans On Infecting 2,000 More Before 2017 - TRENDING”
Although Chinese domestic suppliers have expanded their market share to 32.7% in 2016, the trend was reversed in 2017, as their share shrank to 26.8%, said Qu Daokui, president of China Robot Industry Alliance.
大众创业,万众创新

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
From the themed collection: 住进“甲醛房” 老租客心里慌
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

From the themed collection: 下一轮调控重点须从房价转向地价
Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

这段深入11岁女孩心灵与情感的旅程可能是皮克斯迄今最疯狂的冒险。这是一部非常有趣的工作场合情景喜剧,艾米·波勒(Amy Poehler)、菲利丝·史密斯(Phyllis Smith)和敏迪·卡灵(Mindy Kaling)等人带来了精彩感人的演出,这是一则关于心理发展的精巧语言,也是对于悲伤在我们的生活中所扮演的角色的一种感人而诚恳的辩护。

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

"The Chinese government, universities and investors have provided a friendly environment for young startups. However, the failure rate of fresh graduates founding startups is still too high due to the lack of experience, resources and networking," said Wang Yixin, a senior consultant at Zhaopin.

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

[stik]
Don't lie about your salary. Ever. Even if your employer doesn't tell us (and most do), we'll find out eventually. I've terminated two people for doing that.

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

就业是经济发展的基础,是财富增长的来源,也是居民收入的主渠道。
manifesto
Only two people know the Oscars winners list and supervise the counting procedures - PwC tax adviser Martha Ruiz and Brian Cullinan an accountant.
当城市规划部门明年初(2015年——译注)提出初步的建议方案时,布鲁克林的东纽约(East New York)地区将被列为试点。随后,重新区划进程就将在该处全市最穷社区之一内展开。而紧随其后的,将是针对皇后区的西法拉盛(Flushing)的提案。

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

200911/88510.shtml
v. 使防备,支撑,拉紧,使绷紧

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
From the themed collection: 高端五金配件助力智能化
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

neglect
In 2011 the owner of the tomb was identified as Liu Fei (169BC-127BC) the first king of Jiangdu an autonomous kingdom within the Han Dynasty according to China News.

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

清华大学是国内表现最好的大学,有三项学科的排名进入全球前10。北京大学则是有两项学科排名挤入前十。就清华大学而言,建筑/建成环境和土木/结构工程学均排名第8,材料科学排名第10。

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

报告发现,艺术学、农学、工学专业的学生创业意愿最高,而历史学和理科专业的学生创业兴趣相对较低。
Schools relied on a wide range of technologies to ensure lively interactive delivery of their programmes including virtual classrooms, live sessions and multimedia teaching materials. Alumni were asked to rate delivery as well as indicate how effective online exams were. Results were encouraging. Schools appear to be getting better at online delivery. Every aspect of online delivery was rated higher than it had been in previous years, showing a greater level of satisfaction.
"People should just never walk away and leave their animals," Ms Lewis said. "Everyone has a legal obligation to look after animals in their care."
由于欧元危机的影响,希腊,意大利,葡萄牙以及西班牙的排名大幅下滑。然而下滑幅度最大的是由于近期的政治危机影响的埃及,缅甸,和沙特阿拉伯。

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

寻找工作的雇员并不希望将这些蛛丝马迹被他们的经理发现,凯说,但是他们确实被发现了。
The nations of the world have agreed to try to limit the warming to 3.6 degrees Fahrenheit, which would require that emissions slow down and then largely stop in the next 30 years or so. If they continue on their present course through the century, scientists say, the earth could warm by as much as 10 degrees Fahrenheit above the preindustrial level, which would likely be incompatible with human civilization in its current form.

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

历史会这样回首2012年:这一年,中国“第五代”领导层亮相,同时中国经济转向较低速增长的轨道。这种转变发生的背景,将是一系列令人畏惧的国内挑战——不断增加的社会不安定,不断扩大的收入差距,以及生态和人为的灾难——加上不断升级的外部紧张,这源于美国重新转向亚洲,同时亚太邻国对中国的经济崛起越来越感到忧虑。
跳水游泳花样游泳篮球小轮车曲棍球田径
Around 10 gigabytes of photos have allegedly been released. Jiedaibao, a popular online peer-to-peer lending platform, is involved in the incident, the Beijing Times reported on Dec. 1.

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

People with Type A personalities are often high-achieving "workaholics". They push themselves with deadlines, and hate both delays and ambivalence. People with Type A personalities experience more job-related stress and less job satisfaction.
佳士得珠宝部门的国际高级鉴定师吉恩马克·鲁纳尔称:“这颗钻石完美无瑕,从内到外都绝对纯净。”
英国科学家本周一证实,莱斯特市的一个停车场地下挖出的遗骸为15世纪英格兰国王理查三世,这也解开了长达五百年的谜团。

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

Best Companies rank: 63
n. 航行,航海,导航

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

上周二,Snapchat推出了一种名为Discover的服务,Vice、CNN和《人物》杂志等媒体可通过它在Snapchat发布视频内容。已经有几个频道推出广告服务,要价可不便宜。据《广告周刊》报道,Snapchat的广告标价是每天75万美元。
“欧洲工商管理学院极大地充实了我们的跨文化体验,”一位来自瑞士的校友在接受调查时表示,“在这里学习全球文化好于其他任何地方。”
最不淑女奖

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

Kate Winslet is another Brit who’s opted for the loo for her best actress Academy Award, which she was awarded for her complex role as a concentration camp guard in the 2008 adaptation of Bernhard Schlink’s novel, The Reader.
Company: The Grommet

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
From the themed collection: 建材市场发展路在何方?
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

在2017年FT对全球95个管理学硕士项目的排行中,虽然瑞士圣加仑大学(University of St Gallen)继续蝉联冠军,但法国和英国商学院分别以24个和18个项目入围成为中坚力量。超过一半的英国商学院排名上升,而只有一家法国商学院排名上升。三分之一的英国商学院排名上升5位,相比之下,三分之二的法国商学院排名下降5位或更多。
Having said this, don't make a pest of yourself. Nobody wants to hear you ask a question every 10 minutes. If you're completely lost, make an appointment to see your teacher after class.
答:其实我并不怎么关心作品火不火的,就是专注于自己的作品而已。每次我关注的就是要怎样用最好地推进剧情而已。我关注的是行为和故事,不是受欢迎程度。

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

Mr Erdogan, who has also benefited domestically from the row with Mr Rutte, has sought to broaden his diplomatic dispute to take on all of the EU, particularly Germany, which has had similar run-ins with Ankara over campaigning in Germany’s large Turkish community.

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

除了你的华生,他会觉得这样的你性感极了!
The American Film Institute has picked its 10 best movies and TV shows of the year. The titles, presented in alphabetical order, are works AFI's juries have determined advance the art of the moving image, enhance the cultural heritage of America's art form, inspire audiences and artists and make a mark on American society.

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

谁也不愿意自己的家门口整天闹个不停。
7月,中国网络上突然疯传一对情侣在北京一间优衣库的试衣间里做爱的视频。有评论猜测这是优衣库的宣传噱头,但该店否认了这种说法。数人因涉嫌上传及传播该视频而被捕。

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

库什纳回忆道,我当时被他深深折服了。他到新闻集团去见默多克时,我与他有了第一次接触,当时我被一同叫去提提意见。达洛伊西奥在会上描述了他想要实现的远景。他帮助默多克加深了对一些事物的见解。达洛伊西奥在台上的优异表现,加上背后李嘉诚的雄厚财力,为Summly招来了包括艾什顿?库奇(Ashton Kutcher)、小野洋子(Yoko Ono)、史蒂芬?弗莱(Stephen Fry)等许多人的捐赠。
5) I take a gloomy view of things 0 1 2 3 4

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
From the themed collection: 武汉启用新存量房买卖和居间合同
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

野村证券(Nomura)的分析师表示:“我们预期这一轮出口增长的反弹不会维持很长时间,未来数月增长势头将恢复温和,原因是人民币的升值可能弱化中国的出口竞争力,且即使习主席和特朗普总统近期在北京会面,发生贸易摩擦的潜在风险并未显著减轻。”
信中写道:“英国时装协会不应该认可这种生产如此残酷,甚至在英国是非法的材料。

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

And while there is still a long way to go before airplanes designed and made in China compete on the world stage with the likes of the Boeing 737 or Airbus A320, the momentum is there, and the country’s aerospace industry is entering a new phase of development and maturity.

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

平均工作经验:费城班10年,旧金山班12年
201001/94005.shtml【英文原文】
TAXES: Approximately $16,866 in 2014
established

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

projected

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

10.专注工作,调节平衡
Matthew McConaughey and Jared Leto both won for their startlingly gaunt performances in the Texas HIV drama 'Dallas Buyers Club.' Leonardo DiCaprio, a nine-time Golden Globe nominee, won his second Globe for best actor in a comedy for his uninhibited work in 'The Wolf of Wall Street.' He thanked director Martin Scorsese for his mentorship ('Wolf' is their fifth film together) and for 'allowing me to stalk you to make this movie.'
D1t]!J^-6h=kwFS)I

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

是否有什么事情我一直放不下?我们不会总是能意识到我们在何时抓住有害但感觉安全熟悉的事情不放手,不论是一份不称心的工作,还是一段不健康的关系或者一种停滞不前的生活方式。看看你是否执着于对你没用的事情,想出小措施来改变和解脱吧。
5.《出租车司机》

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

The history of James Bond theme songs isn't quite as long as some might suspect, however. The first two films in the series – Dr. No and From Russia With Love – didn't have opening songs, they had orchestral arrangements. Dr. No even segued into a weird rendition of "Three Blind Mice." Later on, On Her Majesty's Secret Service gave the opening number amiss and snuck its theme song into the middle and end of the movie.
Recruits are expected to have a decent degree result — a 2.1 or above. While academic credentials are important, Teach First also looks for personal skills such as humility, respect and empathy. Applications to join the scheme outnumber the places available by seven to one.

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
From the themed collection: 定制家具退货难 选对品牌是王道
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

Other European cities have seen increases in costs, pushing them up the rankings. London rose five points, bringing it into the top 10.

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
From the themed collection: 家居上市企业中报8月密集披露
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

China's consumer price inflation decelerated to just 1.3 per cent year-on-year last month, the slowest rate since May. On a month-to-month basis inflation fell by 0.3 per cent, the first negative reading since May.
债券大王比尔?格罗斯(Bill Gross)承认:“QE必须结束。”数万亿的低成本资金“扭曲了激励机制,将资产价格推高至人为水平”。但现在格罗斯说“美联储的计划可能过于仓促了”。
All three of the big worldwide financial bubbles that have blow up in the last three decades have 'been fueled by the Fed keeping policy rates below the nominal growth rate of the economy far too long, ' says global strategist Kit Juckes of the French bank Societe Generale.

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

Supporting Actor in a Limited Series or Movie: Sterling K. Brown, “The People v. O. J. Simpson: American Crime Story”
Singer Susan Boyle came undone -- literally, when her trousers popped open at a soccer match as she waved a Celtic fan above her head in Scotland. The "Britain
9. 安布罗斯·阿钦摩西尔(Ambrose Akinmusire),《想像中的救世主更容易描绘》(the imagined savior is far easier to paint),Blue Note。小号手安布罗斯·阿钦摩西尔为自己在Blue Note公司发行的第二张专辑注入了类型不固定,富于探索精神的今日之声,有许多歌手和一支弦乐四重奏组合参与。和这张专辑刚发行的时候相比,如今的他有了更多评论社会的迫切与讥讽时局的精神。
中国国产3D奇幻/冒险片《捉妖记》2015年7月在国内上映后打破一系列票房纪录,成为2015年中国内地最卖座的电影

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

“在香港地区,房地产的基本面明显放慢下来,”他说,“我减持了一点儿,然后很快发生了全面调整,所以我等到反弹后,卖出了一部分。”
周三,北京市发改委主任卢彦在新闻发布会上说:“我们将会在通州开展297个项目,例如建设地铁线和高速路及改善生态环境。”

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
From the themed collection: 南安加强石材陶瓷 粉尘综合整治
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

castle
1Switzerland
2002年,电视剧《绝望主妇》的制片人马克·切利正在家和他母亲看着电视。那天(以及前几天)的头条新闻是安德烈·耶茨案件审判。她因在浴缸里溺死自己的5个孩子而受审。马克转身问他母亲:"你能想象一个女人究竟是多么绝望才会杀了亲生孩子?"

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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About this collection

马科斯卡瓦略是一名18岁的巴西球迷,本周早些时候,在巴西利亚国家体育馆闲逛的他表示:“我们甚至压根就没想过买票这事。门票太贵了,我们根本买不起,能做的也就是在家看看球了。我们看着去那些现场观战兴高采烈的人们,但我们自己却去不了,这真令人难过。”
该报告显示,社交媒体,尤其是微信,过去一年里在40岁以上人群中变得越来越受欢迎。

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