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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

'Gangnam Style' beat 'Call Me Maybe' as the most trending pop song and 'Skyfall' topped 'Prometheus' as the most enquired about film.
研究人员表示,去年之所以特别引人瞩目,是因为除了1月和4月以外,每个月都会创下新的全球高温记录,或与记录持平。

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

movement
新年就要到了,让我们给那些久未联系的朋友送封英文新年祝福邮件,表达一份深深的祝福吧!

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

一有机会就炫一下小卷毛。

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

10.《萤火虫》灵感来自葛底斯堡战役

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

法国兴业银行(Societe Generale)国际策略师基特?朱克斯(Kit Juckes)说,过去30年破灭的三个世界级金融大泡沫背后,都是“美联储(Fed)太久时间将政策利率维持在名义经济增长率之下”。
Had the North Koreans not set off another nuclear test at the weekend the big story this week on the Korean peninsula might have been the Trump administration’s odd timing in announcing its plans to pull out of a trade deal with Seoul.
“Our population and employment is at an all-time high and growing. That puts significant pressure on rents and prices,” said Mark Willis, the executive director of the New York University Furman Center for Real Estate and Urban Policy. “There is no reason now to think that these trends are likely to change.”
In the wake of the Fitbit and Google’s GOOG 0.26% Glass, a flurry of companies has flooded the market with iterations of sensor-laden armbands, apparel, and eyewear. It’s a buzzy category, but early adopters seem to be waiting for a moment when they are no longerthat guy. (You know. The “Glasshole.”)

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

警方周四表示,关于14岁少女Lecent Ross的枪击案,已逮捕两人。
在这个力求避免任何歧视的态度的年代,年轻一代开始不满邦德的大男子主义态度和不健康的生活方式,因此赫洛维兹引入了一系列会指出邦德错误的新人物。
Nicole Kidman had daughter Sunday Rose at age 40, with her husband, the country singer Keith Urban. 妮可·基德曼40岁时和其丈夫,乡村歌手凯斯·厄本生下女儿桑迪·
但是随着西方制造业和工业的衰落,不少工薪阶层市镇也随之衰败,父母和祖父母们发现,下一代已经不能拥有他们曾经拥有的机会了。

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

Though the 60-year-old Microsoft head is 4.2 billion dollars poorer than 2015, his net worth of 75 billion dollars has put him in the top spot of the spot on Forbes' World Billionaires list for the third year in a row, after overcoming Mexico's Carlos Slim Helu in 2014.

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

Pork prices, which are heavily weighted in the food-focused basket of goods used to calculate consumer inflation, rose 4.8 per cent.

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

最后的预言:疲软的经济增长将延续至2010年。在春天前,奥巴马的白宫都不得不扮演美国政治中心的角色,美国商业界也终于开始相信会出现温和复苏。
Currency movements have had a strong impact on agricultural commodity prices this year, with the UK’s referendum on the EU leading to a sharp fall in the pound that pushed up the price of food imports and boosted agricultural exports.

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
From the themed collection: 网站不能随意发布房源
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

《二十二》讲述的是22名慰安妇的故事,是中国首部票房超过1亿元的纪录片。
“A worker sent a text to a colleague saying he was quitting and asked her to forward it to management.”

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

如今,蓬勃发展的互联网经济在支撑我国信息技术(IT)行业财富增长方面正发挥着越来越重要的作用。
May the glow of New Year candle fill your heart with peace and pleasure and make your New Year bright.

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

I experienced this pessimism personally in Davos in January 2014. Several leading western intellectuals asked me whether war would break out between China and Japan. I was so confident that there would be no war in east Asia that I offered to take bets with ten-to-one odds against myself with eminent western journalists. Two took up my bets. And I will be collecting on these bets when I return to Davos in January.
Four other domestic movies made it to the top ten list, among them are the third winner Never Say Die, Kung Fu Yoga in the fourth place, the fifth winner Journey to the West: The Demons Strike Back, and Youth in the eighth place.
泰勒·斯威夫特和凯蒂·佩里选择了两种样式完全不同的极为诱人的礼服。泰勒选择了一款能够展现她修长身材的传统好莱坞式、迷人的古希腊风格的露背礼服,而凯蒂则穿着一件更短的、更有活力的礼服,每个地方都露了一点。
Beijing targets consumer prices inflation at 3.5 per cent, but weakening growth is keeping prices benign.

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

As well as diversity, Mr Cook has championed sustainability and supply-chain transparency, including a commitment to reducing Apple’s use of conflict minerals. While hyper-efficient under Mr Cook’s management before he became chief executive, Apple’s supply chain has not always been something to boast about, with recurring complaints about working conditions.

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

Three stricts and three honests: Be strict in morals, power and disciplining oneself; be honest in decisions, business and behavior
Colliding Neutron Stars

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

Not until recently anyway. But scientists at Weill Cornell Medical College have at last managed to—at least with mice and monkeys. This produced artificial retinas, whose chips convert images into electronic signals and whose tiny projectors convert electronic signals into light.

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

ICBC said net profits increased 0.5 per cent for the year to December 31 2015 — the smallest increase since it listed. Returns on average total assets declined 0.1 percentage points to 1.30 per cent.

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

1=不全是
沃伦·巴菲特自2014年以来再次排名第二,净资产由去年的608亿美元增加到756亿美元。
“I think the best way to engage young people in the process is to win,” he says.
沿海江苏省的无锡市以4.9%的环比涨幅连续第二个月处于首位。

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

The book reflects growing anxiety in some quarters about the possible negative impact of automation on jobs, from manufacturing to professional services. The subtitle of its UK edition warns of “the threat of mass unemployment” and, in the US edition, foresees “a jobless future”.
The 2011 Nobel Peace Prize has been awarded to Liberian President Ellen Johnson Sirleaf, Liberian peace activist Leymah Gbowee and Yemeni women's rights advocate Tawakkul Karman.
虽然总统那晚险胜,此次相逢与前两次辩论相比是诚恳且基本上平安无事的,不太可能对选举结果产生多大的影响。
他们必须发自内心地明白,通过操纵选举、打击异见或者骚扰反对派让临时权力永久化是不合法的。
达奇斯说:三菱每况愈下。低销售量使得公司作出决定,退出欧洲市场。如果负面的讨论可以看成是失败的迹象,那么公司在2013年看上去也不会有多好。

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

*剧情类最佳客串女演员:玛格?马丁戴尔(Margo Martindale),《美国谍梦》(The Americans)
三个泡沫分别是:20世纪90年代初的亚洲泡沫,90年代晚期的互联网泡沫,以及在2008年引起华尔街崩盘的那次泡沫,朱克斯称之为“信贷大泡沫”(Great Big Credit Bubble)。

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

毕竟,在最新一批时装系列中,最引人注目的系列有流线形的趋势,没有被任何与60年代有关的元素或身份拖住——例如,路易威登(Louis Vuitton)、迪奥(Dior)、普罗恩萨·施罗(Proenza Schouler)和纳西索·罗德里格斯(Narciso Rodriguez)——这些服装大踏步走向未来,没有往昔的负累。

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

1.《宋飞正传》"踢脚舞"一集差点流产

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
From the themed collection: 2017年门窗行业大事盘点
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

《傲骨贤妻》(The Good Wife):艾丽西娅(Alicia)的秘密暧昧对象威尔(Will,乔希·查尔斯[Josh Charles]饰)在第五季末死去,CBS频道的这部性感法庭剧似乎要完蛋了,但是第六季却似乎充满了疯狂的能量——艾丽西娅初露头角的政治竞选、新旧公司的权力之争、合伙人卡里(Cary)的棘手法律事务。艾丽西娅不再那么完美,《傲骨贤妻》因此更好看了。
The index fell from 50.4 in October to a six-month low of 50.0.
6. "How I Met Your Mother" (3.0 million)
不过,中国的手机制造商却在2016年实现了崛起。华为出货量同比增长了30.2%,达到了1.393亿台,再次排在全球第三。

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

Then why do you go out and do the things you tell us not to do? 你们大人为什么去做与你们教导孩子相反的事情呢?
针对那些对比较世界各地的学校有兴趣的学生,《美国新闻与世界报道》近日发布了第四版全球最佳大学年度排行榜。
If you plan to visit Brazil for the Olympic games, and to focus on sport and having fun, Google has you covered. In anticipation of the 2016 Rio Olympics, the search giant is bringing the 'Explore' feature to Brazil Maps.
"Migration should be an option, a choice. But for 200 million people, it's a necessity," he told the Thomson Reuters Foundation in a phone interview.

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

Piggyback riders are designed especially for small children and toddlers, to lessen the parents’ struggles.
[mɑ:sk]

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
From the themed collection: 中国家居品牌博览会在圣保罗开幕
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

Airbnb Showdown
6. Google Adwords Keyword Planner
But Gitanjali's portable invention allows a sensor linked to a mobile app to give an accurate, almost immediate analysis.
8月12日,港口城市天津的一座非法储存危险化学品的仓库发生一连串爆炸,导致173人死亡,数百人受伤,造成的破坏景象仿佛末日来袭。此次爆炸事件提出了有关中国在快速工业化进程中安全监管松懈的严肃问题。
As the calendar flips to December it’s not too early to think about the inevitability of tanking. Who should do it, who should wait, and who shouldn’t ever consider it. Flanns and Zillz discuss.

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

在可预见的未来,我国会见证第三产业的繁荣发展。该报告称,相关专业,包括法律、新闻传播和管理学,预计将扮演更重要的角色。
Starbucks CEO Howard Schultz
在婴儿出生前治疗出生缺陷

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

你的老板很差
An employee in the public relations department at Tencent Holdings, operator of a live-broadcast app through which a man received online payments of more than 250,000 yuan ($36,400) from a 13-year-old girl for his singing talent, said the girl might have faked her age when registering.

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
From the themed collection: 5月 限竞房销售新规落地
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

On Monday the research team said the skeleton confirmed that the monarch had severe scoliosis, or twisting of the spine. It may have been painful and caused his right shoulder to appear higher than his left, but there was no evidence of the withered arm depicted in Shakespeare's "Richard III".
n. 释放,让渡,发行
彭博(Bloomberg)的调查分析此前预计1月份中国CPI应上升1.9%。

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

WORST GREETING
Winners: Mavericks
不过,这一增幅低于8月份到9月份3个百分点的增加幅度,意味着近期的房地产限购措施或许产生了一定效果。

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

那么,当你看到17岁的尼克?达洛伊西奥(Nick D’Aloisio)意气风发地走进伦敦巴尔?布鲁(Bar Boulud)餐厅,与人坚定地握着手,描绘他未来事业蓝图的时候,你应该会惊讶得合不拢嘴了吧。他就像是个来自硅谷的首席执行长(CEO),应对媒体时从容不迫,技巧上可以打97的高分。聊天时,他眼神坚定地注视着你,从诺姆?乔姆斯基(Noam Chomsky)的理论、神经网络科学,到移民心态乃至佛教瑜伽,他一切话题都能自信地畅所欲言。但他又像是个One Direction男孩组合的成员,修长的身材配着嬉皮T恤和修身小西装,头发凌乱地搭在脑门前,一边咬着吉士汉堡,一边发表着让人瞠目结舌的见解。

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

国家已出台多项措施来推动新能源汽车,包括免税、发放购车补贴,以及要求政府部门购买更多的新能源汽车。

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

Rounding out the top three is Fleetwood Mac at $59.5 million. Though the band contains three men, it also boasts two high-profile ladies—Stevie Nicks and the recently-returned Christine McVie—rendering the group eligible for this list. Its On With The Show tour included 86 concerts during our scoring period, grossing well over $1 million per city.
《失常》,导演查理·考夫曼(Charlie Kaufman)与杜克·约翰逊(Duke Johnson)。

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
From the themed collection: “复合32.5”水泥停产倒计时
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

commission
? Heavy snow has fallen in West Virginia, with up to 17 inches in Webster Springs. The National Weather Service has warned that more is on the way.
5. It's a dog's life for the British
Vegetable price growth more than doubled to 13 per cent year on year, helping push food inflation to 3 per cent, up from 2.7 per cent in September.

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

The discovery has caused huge excitement among historians, as it provides firm evidence about a monarch whose life has been shrouded in controversy since his death at the Battle of Bosworth in 1485.
As E.E. Cummings rightly said, "To be nobody but yourself in a world which is doing its best, night and day, to make you everybody else means to fight the hardest battle which any human being can fight; and never stop fighting."

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

'In the next 12 to 24 months, unless any of these bottlenecks are solved, we could see WTI going down to $50 a barrel, to incentivize producers to slow down,' she said
这支队伍需要更多的天赋,他们需要大修。对魔术而言,最能吸引天赋到来的方式一直以来都是选秀。

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

黄记泳表示,去年赴韩旅游的中国游客超过800万人,同比增长36%。他还表示,甚至在韩国政府宣布部署萨德之后,该数字也曾继续上升。

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

赫梅尔说,“如果发达经济体的原油需求增加,再加上新兴经济体需求的增多,我认为市场供应将趋紧。”这意味着油价走势图上可能会再度出现多个高峰。
He admitted to having mixed emotions about the letter as he and Vonnie are now divorced.
谁被埋葬在这里?
说到这一点,你要注意的是,不要影响其他的人。没有人想每隔十分钟就听到你提问一次。如果你实在是不懂的话,可以在课后约上老师再讨论。

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
From the themed collection: 家居市场逢淡季 商家联盟求突破
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

在纽约市许多公寓楼的大门背后,充斥着居民们不协调的抱怨声。从我的“房地产答疑”(Ask Real Estate)专栏所收到的抱怨信中,我们可以一窥居民们是如何应对生活在拥挤、昂贵的住房中的种种不顺心的。比方说,有个合作公寓的股东被邻居家的老鼠窝吓坏了;有一对父母被禁止将婴儿车推进楼内的电梯;有个租户厨房里的橱柜从墙壁上掉了下来。
v. 从事运

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
From the themed collection: 逆势增长 呈进境木材新亮点
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

The Lord of the Rings trilogy. The amount of time before I need an oil change. My cell phone's battery charge. What do all of these things have in common? The
据《外交政策》网站报道,在通往世界杯奖杯的漫漫征程中,比利时和乌拉圭是夺冠热门球队希望避开的两座冰山。在今年的世界杯赛场上,尽管比利时和乌拉圭都是不起眼的小角色,但它们有能力让比盲目自信的对手喝上一壶。虽然它们是历史上的小国,地缘政治上的出气筒,但很明显,他们在足球场上仍然极具竞争力。
The Caixin-sponsored series is based on a much smaller sample of private companies than the official PMI reading, which focuses on larger state enterprises, and tends to be more volatile.

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

Granted, it is easier to remake something than to make something new. Anyone who has faced a blank page knows that. But if fashion’s ubiquitous default to the 1960s over the last seven years has exposed anything, it is its own lack of imagination, not only about clothes and consumers, but about the relationship of culture and dress.
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Last year, the CPI increase peaked at 2.5 percent in January, and later fluctuated below 2 percent during the rest of the year.

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

在这个被大型地产开发商主宰的市场,结构性挑战通常成为抑制欧美大型资产管理公司的因素。
桑尼伯恩和他的父母以及11岁的妹妹朱莉娅住在佛蒙特州的布里斯托尔,他正在寻求民主党的提名。

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

China has all long and continues to support a united, prosperous and stable European Union, support a strong Euro, and support European integration process. We believe that is good for globalization, for a multipolar world and for diversity of civilizations. We feel optimistic about the future of the EU and the future of China-EU relations.
The pickup in consumption in turn will entice businesses to hire and invest more to keep up with rising sales. The result: The U.S. is likely to grow more than 3% for the first time since 2005.
据上周一发布的全球创新指数显示,中国成为首个跻身世界最具创新力经济体25强的中等收入国家。

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

copyright
平均月薪最高的为IT/互联网/通讯/电子行业,应届生平均薪资水平为5693元;其次是金融行业和文化/体育/娱乐/传媒,平均薪资水平分别为4685元和4552元;农/林/牧/渔/其他、服务业和文教体育/工艺美术是应届生签约行业中薪资水平较低的行业,月薪分别为3500元、3873元和3900元。

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

It was Somerset Maugham who said the French Riviera is “a sunny place for shady people” – and looking around at all the 'models' in the hotel lobbies and the men in dark sunglasses who seemed to know them, I knew what he meant. Behind the festival's shiny facade, there is an unseemly side – and beneath the azure waters, a polluted mess. The French diver and environmentalist Laurent Lombard's video of the Cannes seabed strewn with waste and debris went viral before the festival began. We were assured there was no danger to swimmers, and the mayor had it cleaned up according to the Daily Mail – but the Med had certainly lost some of its sparkle.
We will move forward with ecological conservation and improvement.
然而,3月份以17美元的发行价上市的Snap,在最初上涨后下跌至约15美元,打击了市场对于所谓“十角兽”企业(通过私人筹资达到100亿美元或更高估值的公司)会有更多IPO活动的预期。

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

WORST USE OF SOCIAL MEDIA

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

While there is a still a way to go to ensure the LGBT community has the same rights as sexual couples, the world has moved on significantly in recent years. In fact, gay marriage is now legal for 60% of Americans. What about the other 40%, you ask? The List Love really believes the rest of the United States, and many other countries across the world – we’re talking to you, Russia! -will catch up soon.
毫不奇怪,信贷具有“助周期性”。当资产价格一片繁荣时,乐观的贷款机构倾向于发放更多贷款,进而加剧市场的狂欢。当资产价格下跌时,贷款机构会控制风险,有时这种做法会加速下跌。

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

The book reflects growing anxiety in some quarters about the possible negative impact of automation on jobs, from manufacturing to professional services. The subtitle of its UK edition warns of “the threat of mass unemployment” and, in the US edition, foresees “a jobless future”.
5. It's a dog's life for the British

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
From the themed collection: 中国建材升级引国际巨头关注
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

Mr Baweja agrees with this conclusion, noting that both South Korea and India, another net commodity importer, are exporters of refined oil products, the dollar value of which should rise this year.
优秀的老板们懂得授权的艺术。我的一位评论家说要沿着线走“他们已经从目前的工作里面抽身”,意味着他们不干涉每一天和每一分的工作流程和程序。本质上,学着去授权给员工去代替微化管理是对员工的一种信任。

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

随着威斯布鲁克成为一个事事亲为和高使用率的角色,奥拉迪波固定成为一个昂贵的补充品,佩恩需要证明他无球时的威胁力、或是能成为带动第二阵容的后卫,
Yet if “Mad Men” showed us anything (besides how cool a skinny suit could look, and that wide ties really were not a good men’s wear moment), it is that the decade chronicled was a complicated, often unhappy, occasionally destructive time.

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

用走私野生动物制成的商品到哪里去了?

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

电视剧版《何以笙箫默》改编自顾漫同名小说,由钟汉良和唐嫣主演,2015年1月首播。它讲述了一对情侣分离7年后重逢,一个执着于等待和相爱的故事。这部小说一直是网络小说中的佼佼者,并于2003年出版。凭借完美情人何以琛一角,演员钟汉良迅速跻身为女粉丝心中的白马王子。
2. 在原来工作岗位上呆太久了
3.2 深化重要领域和关键环节改革
celebrity

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

“If we can identify someone who buys in both places, there is huge value there. You know who they are, what they bought, what they spent,” Harper added. “You can give them a more personalized experience.”

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

On Monday the research team said the skeleton confirmed that the monarch had severe scoliosis, or twisting of the spine. It may have been painful and caused his right shoulder to appear higher than his left, but there was no evidence of the withered arm depicted in Shakespeare's "Richard III".
基因疗法发展良好。
"Although it may seem counterintuitive, the best way to maximize profits over the long-term is not to make them the primary goal of the business," Mackey said in an interview earlier this year.

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

徐成光在新闻发布会上表示,截至上午10时20分,已打捞出97具遗体。
6. statuesque / a . 高大匀称的,体态优美的。

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

对于可治疗的癌症,非洲人有了新的希望。
The history of James Bond theme songs isn't quite as long as some might suspect, however. The first two films in the series – Dr. No and From Russia With Love – didn't have opening songs, they had orchestral arrangements. Dr. No even segued into a weird rendition of "Three Blind Mice." Later on, On Her Majesty's Secret Service gave the opening number amiss and snuck its theme song into the middle and end of the movie.

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
From the themed collection: 本土企业与进口地板的市场PK战
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

报告发现,艺术学、农学、工学专业的学生创业意愿最高,而历史学和理科专业的学生创业兴趣相对较低。

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

Heatwaves around the world, including one in India that led to more than 2,000 deaths and another in Iraq that saw the mercury top 50C, helped push temperatures 1C above pre-industrial levels for the first time, US and UK researchers said.
而汇丰银行(HSBC)则表示,上个月该行自己发布的中国制造业PMI指数显示出了制造业停止扩张的现象,从而确认了此前已发布的“预览版”估值。
Over 10- and 20-year stretches, geographic and asset class diversification have proven beneficial for returns and risk management. Unfortunately, you are not guaranteed to see the benefits of such a strategy during any 12-month period. In an era of 140-character writing and two-minute video, should we be surprised that investors have trouble judging the success of their portfolios over long periods?

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

Perhaps the more interesting question is what drove Yahoo! to shell out that reported $30 million for a single app. To be sure, Summly's text-compression abilities dovetail nicely with Yahoo!'s new focus on mobile utilities. Along with Yahoo!'s $1.1 billion purchase of the blogging service Tumblr and the launch of an acclaimed new weather app, the Summly move marks a commitment to owning the tiny real estate of the smartphone screen-and serving advertising to the youthful eyeballs that tend to gravitate to mobile devices.
The rest of the top 10 2016 highest-paid actresses are:
Plenty of dark clouds loom over the U.S. job market -- particularly the potential double-punch of tax increases and spending cuts known as the fiscal cliff.[qh]
现在的勇士队已经是NBA历史上最好的球队之一,你可以把他们的冠军阵容和NBA历史上的任何一支球队相提并论,因为他们打出了有史以来最好的季后赛表现。但同时也有一个“篮球”的问题。如果历史上最好的或者第二好的球员都没有机会对抗这支球队,那对这项运动的竞争力意味着什么呢?到目前为止,幸运的是这个问题并没有凸显出来,这可多亏了一个非常狂野的休赛期,但问题仍然存在:当一个最高水品的竞技体育联赛缺乏真正的竞争时,它会发生什么?

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

The main culprit for the deceleration was food, though food inflation is higher than the overall index. Food prices were up 1.9 per cent in October, down from 2.7 per cent in September and 3.7 per cent in August. Non-food inflation ticked down 0.9 per cent from 1.0 per cent.
台风哈维

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

但对于北京来说,若能在特朗普让美国退出TPP后不到一年的时间里达成RCEP协议,将是一场巨大的胜利。
China purchased 141,000 industrial robots in 2017, up 58.1% year-on-year, but foreign brands accounted for nearly three quarters of that, showing that the gap is still widening between Chinese robot makers and their foreign peers.
[s?:'vei]

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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About this collection

电子商务巨头亚马逊首次进入汤森路透2015年全球创新百强名单,而世界上最大科技服务公司IBM却未能上榜。
该排行榜为有工作经验的高级管理人员评出全球最优秀的100个EMBA项目。

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